Purchase this article with an account.
JW Kiel, HA Reitsamer, A Doelemeyer; Effect Of Dopamine D1 Antagonist On Ciliary Blood Flow And Aqueous Flow In Rabbits . Invest. Ophthalmol. Vis. Sci. 2002;43(13):3275.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
Purpose: In a previous study, we found that intravenous infusion of dopamine causes dose-dependent, parallel changes in ciliary blood flow and aqueous flow, with vasodilation and increased aqueous flow occurring at a low dose and vasoconstriction and decreased aqueous flow occurring at a higher dose. In the present study, we sought to determine the extent of endogenous dopaminergic D1 receptor activation. Methods: Two groups of anesthetized rabbits were instrumented with an ear artery cannula to measure mean arterial pressure (MAP), a vitreous cannula to measure IOP, and a catheter in the orbital venous sinus to measure orbital venous pressure (OVP). In one group (n=12), aqueous flow was measured by fluorophotometry. In the other group (n=7), ciliary blood flow was measured by laser Doppler flowmetry. Measurements were performed before and after giving the D1 antagonist SCH-23390 (250 µ g/kg, iv). Results: View OriginalDownload SlideView OriginalDownload Slide SCH-23390 did not alter baseline ciliary blood flow or the ciliary pressure-flow relationship. Conclusion: The anesthetized rabbit eye receives tonic dopaminergic input. Loss of D1 activation causes increased aqueous production, and slight decreases in orbital venous pressure and IOP.
This PDF is available to Subscribers Only