December 2002
Volume 43, Issue 13
Free
ARVO Annual Meeting Abstract  |   December 2002
Epilepsy Patients Exhibit Compromised Ocular Perfusion Characteristics
Author Affiliations & Notes
  • SL Hosking
    Neurosciences Research Institute Aston University Birmingham United Kingdom
  • EJ Roff-Hilton
    Neurosciences Research Institute Aston University Birmingham United Kingdom
  • SJ Embleton
    Neurosciences Research Institute Aston University Birmingham United Kingdom
  • T Betts
    Birmingham University Seizure Clinic Queen Elizabeth Psychiatric Hospital Birmingham United Kingdom
  • Footnotes
    Commercial Relationships   S.L. Hosking, None; E.J. Roff-Hilton, None; S.J. Embleton, None; T. Betts, None. Grant Identification: Support: Aventis
Investigative Ophthalmology & Visual Science December 2002, Vol.43, 3294. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      SL Hosking, EJ Roff-Hilton, SJ Embleton, T Betts; Epilepsy Patients Exhibit Compromised Ocular Perfusion Characteristics . Invest. Ophthalmol. Vis. Sci. 2002;43(13):3294.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Abstract: : Purpose: Reduced cerebral blood flow and decreased cerebral metabolic rate for glucose have been previously identified in patients with epilepsy. The purpose of this study was to determine whether ocular haemodynamics are similarly reduced in patients with epilepsy. Methods: Scanning laser Doppler flowmetry was used to measure retinal capillary microvascular flow, volume and velocity in the temporal neuroretinal rim of 14 patients diagnosed with epilepsy (mean age 42.0 0.9 years). These values were compared to a normal subject group (n=14, mean age 41.7 0.3 years). Student’s unpaired 2-tailed t-tests were used to compare ocular blood flow parameters between the epilepsy and normal subject group (p<0.05; Bonferroni corrected). Results: Significantly lower retinal blood volume (p=0.003), flow (p=0.001) and velocity (p=0.001) was observed in the epilepsy group (13.52 3.75 AU, 219.14 76.61 AU & 0.77 0.269 AU respectively) compared to the normal subject group (19.02 5.11 AU, 344.03 93.03 AU & 1.17 0.301 AU respectively). Overall, the percentage mean difference between the epilepsy and normal group was 28.92% for volume, 36.31% for flow and 34.19% for velocity. Conclusion: Patients with epilepsy exhibit reductions in neuroretinal capillary blood volume, velocity and flow compared to normal subjects. A reduction in ocular perfusion may have implications on visual function in people with epilepsy.

Keywords: 331 blood supply • 390 drug toxicity/drug effects • 554 retina 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×