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K Schwanitz, MF Mueller, LE Pillunat; Effect Of Isovolemic Hemodilution On Retrobulbar Hemodynamics In Disorders Of Ocular Perfusion . Invest. Ophthalmol. Vis. Sci. 2002;43(13):3299.
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Purpose: The therapeutic benefit of isovolemic Hemodilution treatment (IHT) in vascular occlusive eye disease is controversial dicussed. Aim of the study was to evaluate the effect of IHT on occular hemodynamics. Method: In a prospective, clinical trial we examined 54 eyes from 27 patients suffering from vascular occlusive disease (VOD) (17 male/10 female, average age 62.8 years) 11 arterial (1 CRAO, 4 BAO, 4 AION, 2 PION), 19 venous (5 CRVO, 7 BVO, 7 VSR). Blood flow velocities were measured by means of colour Doppler imaging (Toshiba SSH 140A) in the Central retinal artery (CRA) and vein (CRV), in the ophthalmic artery (OA), in the short posterior ciliary arteries (SPCA), and in the supraorbital vein (SOV) prior and 10 days after start of IHT. Measurements were performed at the affected and the not affected eye. The target hematocrit for the IHT was ? 0.37. For statistical analysis the Man-Whitney-U-test was used. Results: After applying IHT blood flow velocities significantly increased in the syst. OA by 0.17 m/s and diast. OA by 0.066 m/s, and the SPCA by 0.044 m/s (p<0.05) in patients suffering from arterial VOD. In venous VOD a significant (p<0.05) of blood flow velocities was found in all examined vessels (CRA by 0.035 m/s, CRV by 0.019 m/s, SPCA by 0.027 m/s, SOV by 0.041 m/s), except for the OA. The Resistance Index (RI) in arterial VOD remained unchanged after IHT. Conclusion: IHT leads to a significant improvement of blood flow velocities in vascular occlusive disease.
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