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R Seya, A Kanamori, Y Nakasuji, A Eno, H Maeda, M Nakamura, A Negi; Influence of Betaxolol on the Retro Bulbar Blood Flow and Central Visual Field With Normal Tention Glaucoma . Invest. Ophthalmol. Vis. Sci. 2002;43(13):3303.
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Purpose: The purpose of this study was to investigate the effect of betaxolol on optic nerve head blood flow and effect on the rate of visual field loss, when using betaxolol,in patients with normal tention glaucoma . Methods: 22 eyes of 22 patients with normal tention glaucoma were randomly assigned to betaxolol (treatment group ) and 14 eyes of 14 patients were assigned to untreatment control group (untreatment group ). Intra ocular pressure (IOP) and central visual field (Humphrey 30-2 program )were measured at base line and after 6 month. All eyes were underwent color Doppler imaging for measuring peak-systolic velocity, end-diastolic velocity, resistance index( RI ) in the central retinal artery and short posterior ciliary arteries. The data of ocular blood flow and of visual field loss were statistically compared between two groupes Result: Baseline measurements was comparable between the groupes. After six month betaxolol eye drop, the RI was significantly lower in the temporal and nasal short posterior ciliary arteries in the treatment group than in the non treatment group. The RI was slightly low in the central retinal arteries in the treatment group. Intra ocular pressure was significantly reduced only in the treatment group . Conclusion: Most hemodynamic parameters in periocular vessels improved after application of betaxolol in patients with normal tention glaucoma . Betaxolol may be considered as a useful tool for treatment of glaucomatus patient not only because it can reduce intra ocular pressure but also because it can improve the ocular blood supply.
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