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S-H Lee, J Kim, W Jung; The Comparative Study by Timing of Subconjunctival Injection of Mitomycin C in Glaucoma Filtering Surgery in Rabbit Model . Invest. Ophthalmol. Vis. Sci. 2002;43(13):3362.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: To compare surgical outcome based on the time of subconjunctival injection of MMC in glaucoma filtration surgery Methods: Pigmented rabbits were divided into 3 groups according to the injection time of the MMC. Preoperative group that was composed of the 6 eyes of 6 pigmented rabbits underwent subconjunctival injection of 0.01% MMC 0.05ml at the time point of operation 6, 12, and 24 hours before operation, postoperative group that was composed of the 3 eyes of 3 pigmented rabbits underwent 6, 12, 24 hours after operation, and control group the other side eyes of all rabbits underwent during operation. Rabbits were examined periodically by operative microscope after surgery. Histological analysis of eyes performed at 14, 21 and 28th of postoperative day. Results: For gross findings, the blebs in the preoperative and control group were well-formed within the 1st week after operation. The size of the blebs were decreased at 4th week. There was no differences between preoperative and control group. The blebs in the postoperative group were poorly-formed and disappeared within the 2nd week. For LM findings, the cellular infiltration and fibroblastic proliferation in the postoperative group were more prominent than the preoperative and control group. For EM findings, at the 2nd week of operation there was active appearance of the organelles within fibroblasts in the postoperative group, but not in the preoperative and control group. Conclusion: The subconjunctival injection of MMC within 24 hours before and during glaucoma filtration surgery has an similar effect on bleb formation.
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