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S Bae, J Kim, J Lee; Mean Platelet Component in Diabetic Retinopathy . Invest. Ophthalmol. Vis. Sci. 2002;43(13):3481.
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Purpose: To clarify diabetic complications mediated by increased platelet activity, we have studied mean platelet component by a new technique. Methods: We have studied Mean platelet component(MPC) by the automated hematologic analyzer(ADVIA 120, Bayer). PT, aPTT, and fibrinogen were measured to investigate abnormalities of blood viscosity by STA-Compact. MPC was measured in 100 healthy controls and 100 diabetic patients, the latter subdivided according to the absence(25), and severity of retinopathy (Non-proliferative diabetic retinopathy ; 30, Proliferative diabetic retinopathy ; 45). Results: The mean MPC level was 26.9g/dl in control group and 23.8g/dl in diabetic patients (platelet activation was defined as MPC < 26.7g/dl.). The patients with various degrees of retinopathy had similar decreases (p less than 0.05) in their MPC level, while those without complication occupied an intermediate position between normal controls and retinopathy patients. PT and aPTT did not show significant differences between control group and diabetic patients. However, fibrinogen was significant difference (4.31±2.35 g/L vs 3.26±1.14 g/L, p less than 0.05). Conclusion: These results suggest that platelet hyperfunction in diabetic patients may be implicated in the pathogenesis of diabetic retinopathy.
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