December 2002
Volume 43, Issue 13
ARVO Annual Meeting Abstract  |   December 2002
Safety Limit Estimation for UVR-B Induced Cataract as a Function of Age in an In Vivo Rat Model
Author Affiliations & Notes
  • X Dong
    Research Department St Erik's Eye Hospital Karolinska Institutet Stockholm Sweden
  • M Ayala
    Stockholm Sweden
  • M Löfgren
    Stockholm Sweden
  • V Mody
    Stockholm Sweden
  • M Kakar
    Stockholm Sweden
  • P Söderberg
    Stockholm Sweden
  • Footnotes
    Commercial Relationships   X. Dong, None; M. Ayala , None; M. Löfgren , None; V. Mody , None; M. Kakar , None; P. Söderberg , None. Grant Identification: Stiftelsen Kronprinsessan Arbetsnämnd för synskadade, KI Stiftelser
Investigative Ophthalmology & Visual Science December 2002, Vol.43, 3575. doi:
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      X Dong, M Ayala, M Löfgren, V Mody, M Kakar, P Söderberg; Safety Limit Estimation for UVR-B Induced Cataract as a Function of Age in an In Vivo Rat Model . Invest. Ophthalmol. Vis. Sci. 2002;43(13):3575.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract: : Purpose: To investigate the effect of age on ultraviolet radiation-B (UVR-B) induced cataract. To establish safety limits for UVR-B induced cataract in an in vivo rat model. Methods: Female Sprague-Dawley rats were included in seven age-groups: 3, 6, 10, 18, 26, 40, and 60 weeks. Each age group was further subdivided into 5 dose sub-groups. The rats were unilaterally exposed to UVR-B. The incident doses on the cornea ranged from 0 to 9.2 kJ/m2. The rats were sacrificed and the lenses were extracted one week after UVR-B exposure. Intensities of forward light scattering were measured and photographs were taken. The safety limit for UVR-B induced cataract for different age groups was estimated by the maximum tolerable dose (MTD) concept, based on the dose response curve of each age group. Results: TDs estimated for 3, 6, 10, 18, 26, 40 and 60 weeks old rats were 1.8, 2.5, 4.7, 6.1, 6.5, 6.4,and 6.8 kJ/m2, respectively. Conclusion: Younger rats are more sensitive to UVR-B than older rats. Age should be considered for safety limit estimation for UVR-B induced cataract.

Keywords: 338 cataract • 537 radiation damage: light/UV • 316 animal model 

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