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R-F Wang, JB Serle, D Gagliuso, TW Mittag, SM Podos; Effect Of Latanoprost (L) Or Bimatoprost (B) Alone And In Combination On Intraocular Pressure (IOP) In Glaucomatous Monkey Eyes . Invest. Ophthalmol. Vis. Sci. 2002;43(13):4070.
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Purpose: Both L and B are prostaglandin analogues that reduce IOP in patients with ocular hypertension and glaucoma. This study evaluates the possible additivity of effect of L and B on IOP in laser-induced glaucomatous monkey eyes. Methods: Eight monkeys with unilateral glaucoma were divided into two treatment groups. IOP was measured hourly for 6 hrs beginning at 9:30 a.m. on day 1 (baseline day), days 6 and 7 (single agent therapy), and days 13 and 14 (combination therapy with both agents). Following a one day baseline measurement, groups of 4 monkeys were treated either with one drop of 0.005% L or with 0.03% B once daily at 9:30 a.m. on days 2 through 7. On days 8 through 14 L and B were applied once daily 5 minutes apart to both groups. Results: The maximum reduction (p<0.05) of IOP was 6.3 ± 1.9 (mean ± SEM) mmHg (18%) with L alone and was 6.5 ± 1.6 mmHg (18%) with B alone 2 hrs after morning dosing on day 7. A further reduction (p<0.05) of IOP of 4.8 ± 1.3 mmHg (15%) was produced when B was added to L, and 4.3 ± 0.6 mmHg (14%) when L was added to B one hr after morning dosing on day 13. Combination therapy with both agents caused a maximum IOP reduction (p<0.05) from baseline of 10.3 ± 2.2 mmHg (30%) (L+B) and 10.3 ± 0.8 mmHg (29%) (B+L) on day 14, 2 hrs after dosing. Conclusion: Latanoprost and bimatoprost have an apparent additive effect on IOP in glaucomatous monkeys.
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