December 2002
Volume 43, Issue 13
Free
ARVO Annual Meeting Abstract  |   December 2002
Short Posterior Ciliary Artery Dilating Effect of Nipradilol in Rabbits
K Mizuno; T Koide; T Takeno; Y Saino; M Araie
Author Affiliations & Notes
  • K Mizuno
    Pharmacology Tokyo Res Labs Kowa Company Ltd Higashimurayama Japan
  • T Koide
    Pharmacology Tokyo Res Labs Kowa Company Ltd Higashimurayama Japan
  • T Takeno
    Pharmacology Tokyo Res Labs Kowa Company Ltd Higashimurayama Japan
  • Y Saino
    Pharmacology Tokyo Res Labs Kowa Company Ltd Higashimurayama Japan
  • M Araie
    Ophthalmology University of Tokyo School of Medicine Tokyo Japan
  • Footnotes
    Commercial Relationships    K. Mizuno, Kowa Company Ltd E; T. Koide, Kowa Company Ltd E; T. Takeno, Kowa Company Ltd E; Y. Saino, Kowa Company Ltd E; M. Araie, None.
Investigative Ophthalmology & Visual Science December 2002, Vol.43, 4083. doi:
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      K Mizuno, T Koide, T Takeno, Y Saino, M Araie; Short Posterior Ciliary Artery Dilating Effect of Nipradilol in Rabbits . Invest. Ophthalmol. Vis. Sci. 2002;43(13):4083.

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Abstract

Abstract: : Purpose:The aim of this study was to evaluate the short posterior ciliary artery dilating effects of nipradilol in rabbits. Methods:Rabbit short posterior ciliary artery was isolated and pre-contracted with endothelin-1. Vasodilating effect of nipradilol was examined with those of nitroglycerin. Results:Nipradilol and nitroglycerin dilated short posterior ciliary artery dose-dependently with ED50 values of 0.11 µM and 0.15 µM, respectively. Vasodilating action of nipradilol was suppressed significantly by c-PTIO or LY-83583. Conclusion:Nipradilol dilates rabbit short posterior ciliary artery possibly due to activation of soluble gyanylate cyclase and increased production of cGMP that are associated with NO liberated from the nipradilol itself.

Keywords: 491 nitric oxide • 514 pharmacology • 541 receptors: pharmacology/physiology 
© 2002, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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