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K Mizuno, T Koide, T Takeno, Y Saino, M Araie; Short Posterior Ciliary Artery Dilating Effect of Nipradilol in Rabbits . Invest. Ophthalmol. Vis. Sci. 2002;43(13):4083.
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Purpose:The aim of this study was to evaluate the short posterior ciliary artery dilating effects of nipradilol in rabbits. Methods:Rabbit short posterior ciliary artery was isolated and pre-contracted with endothelin-1. Vasodilating effect of nipradilol was examined with those of nitroglycerin. Results:Nipradilol and nitroglycerin dilated short posterior ciliary artery dose-dependently with ED50 values of 0.11 µM and 0.15 µM, respectively. Vasodilating action of nipradilol was suppressed significantly by c-PTIO or LY-83583. Conclusion:Nipradilol dilates rabbit short posterior ciliary artery possibly due to activation of soluble gyanylate cyclase and increased production of cGMP that are associated with NO liberated from the nipradilol itself.
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