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T Mita, Y Ishii, K Mukai, Y Kamei, S Itou, M Matsubara; Histological Change of Cornea by Using Orthokeratology Lens . Invest. Ophthalmol. Vis. Sci. 2002;43(13):4119.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose:To investigate the histological and topographical changes after use of orthokeratology lens. Methods:After being studied cornealtopography, twelve white rabbits wore orthokeratology lens (Euclid Systems Co, USA) on the left eyes for 8 hours daily. Eyes were enucleated after 2, 7, 14 days and 1 month, and served to histological examination. Results:After 7-14 days, epithelial layer were slightly thin in the center of the cornea( 6 mm apical zone) with HE staining. In intermediate zone, epithelial layer was thick and getting thin toward corneal limbus. PAS staining showed no abnormal distribution of glycogen granules or their producing cells. After 1 month, there was no further change in epithelial and stromal configuration. Bulbar conjunctiva showed no abnormality throughout the study. Conclusion:Orthokeratology lens gave the change in the distribution of epithelial thickness. No functional variation was found in both epithelial and stromal layer.
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