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D Freitas, N Santos, L Sousa, M Rigueiro, M Scarpi; Corneal Toxicity of Povidone-Iodine Eye Drops . Invest. Ophthalmol. Vis. Sci. 2002;43(13):4218.
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Purpose:To evaluate the ocular toxicity of povidone iodine eye drops at a concentration of 2.5% and 0.5% and investigate the effects on corneal epithelial wound healing and histopathological alterations Methods:Each group consisted of 20 rabbits. A central circular corneal epithelial defect of 6.5 mm diameter was created and the povidone iodine eyedrops (2.5% and 0.5%, respectively) instilled in the right eye and destilated water in the left eye (control) of each rabbit each hour during 3 days. Biomicroscopical examinations were performed every day, focussing on the corneoconjunctival surface and the diameter of the lesion using fluoresceine eyedrops, fotodocumentation, and a computerized image analyser. After the third day the rabbits were sacrified and the excised corneas evaluated histopathologically. Statistical evaluation was performed using Friedman, Mann-Witney and Wilcoxon tests Results:The povidone iodine eye drops at a concentration of 2.5% caused an increase in the wound healing time (p< 0.001) and conjuntivitis in 100% with mucous secretion in 80%, punctate ceratitis in 40%, and discrete stromal edema in 10% of the cases. The histopathological examination showed corneal ulcers and vacuolic degeneration of the endothelial layer in 100%, as well as an inflammatory infiltrate with eosinophils in 80% of the cases. The eyes treated with povidone iodine eye drops at a concentration of 0.5% and the control eyes showed complete epithelial wound healing after 72 hours and histopathologically normal epitheliazation. Only in one case, a discrete leucocytic infiltrate was observed perilimbar Conclusion:The ocular toxicity of povidone iodine eyedrops is concentration- dependent. The use of the eyedrop at a concentration of 2.5% is not adequate for daily and repetitive use. In contrast at a concentration of 0.5% no toxicity was observed
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