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PJ Lee, AA Moshfeghi, GA Peyman, M Genaidy, DM Moshfeghi, F Ghahramani, S Yoneya; Optimal Timing of Transpupillary Thermotherapy with Indocyanine Green Pretreatment in Pigmented Rabbits . Invest. Ophthalmol. Vis. Sci. 2002;43(13):4413.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: To evaluate the optimal time to initiate transpupillary thermotherapy (TTT) following intravenous (IV) indocyanine green (ICG) injection to induce funduscopically and angiographically visible lesions on pigmented rabbit fundi. Methods: Two pigmented rabbits were used in this study in accordance with the ARVO resolution on the use of animals. Rabbits were treated with TTT alone or following injection of IV ICG (0.41 mg/kg). Time from injection of ICG to administration of TTT varied from 0-15 minutes. An 810-nm diode laser with a slit-lamp delivery system was used to provide a spot size of 3.0 mm for 1 minute of laser exposure at 120 mW. Results: Optimal lesions, as defined by ophthalmoscopy and fluorescein angiography, were created when ICG injection preceded TTT by 5 minutes. Minimal-to-moderate lesions were noted when this interval was shortened (0-2 minutes), while minimal or no lesions were seen when the interval was lengthened (8-15 minutes). Conclusion: In pigmented rabbit fundi, optimal fundus lesions are created when TTT follows IV ICG injection by approximately 5 minutes.
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