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MZ Almeida, JA Cardillo, ME Farah, DC S Calucci, RA Costa; "ThermoDynamic Therapy for Idiopathic and Inflammatory Choroidal Neovascularization - A Preliminary Study" . Invest. Ophthalmol. Vis. Sci. 2002;43(13):4421.
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Purpose: To evaluate the efficacy and safety of ThermoDynamic Therapy in patients with idiopathic or inflammatory subfoveal choroidal neovascularization (CNV). Methods: A prospective, noncomparative small case series. Six patients (7 eyes) with subfoveal CNV were treated with low irradiance 810-nm light and intravenous injection of small-volume, high-concentration indocyanine green (ICG) bolus, termed ThermoDynamic Therapy (TDT). Follow-up time ranged from 6 to 21 weeks (mean 14.5 weeks). Visual acuity testing, fluorescein and indocyanine green angiography as well as optical coherence (OCT) were used to evaluate the results of the treatment. Results: Six eyes (86%) showed an one or more line improvement in visual acuity. In one eye (14%) the visual acuity remained stable. A complete regression of the CNV occurred in five eyes (71%) and two eyes (29%) demonstrated minimal leakage on fluorescein angiography and OCT. There were no complications related to the procedure. Conclusion: In our initial experience with TDT for the treatment of idiopathic and inflammatory subfoveal CNV, reduction or complete regression of the leakage area occurred in all patients without vision loss.
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