December 2002
Volume 43, Issue 13
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ARVO Annual Meeting Abstract  |   December 2002
Intravitreal Triamcinolone Versus Thermodynamic Therapy for Treatment of Choroidal Neovascularization Associated With Retinal Pigment Epithelial Detachment
Author Affiliations & Notes
  • M Skaf
    Ophthalmology Hospital de Olhos de Araraquara Araraquara Brazil
  • PP Bonomo
    Ophthalmology Federal University of Sao Paulo Sao Paulo Brazil
  • ML Abrantes
    Ophthalmology Federal University of Sao Paulo Sao Paulo Brazil
  • ME Farah
    Ophthalmology Federal University of Sao Paulo Sao Paulo Brazil
  • JA Cardillo
    Ophthalmology Federal University of Sao Paulo Araraquara Brazil
  • RA Costa
    Ophthalmology Federal University of Sao Paulo Araraquara Brazil
  • Footnotes
    Commercial Relationships   M. Skaf, None; P.P. Bonomo, None; M.L. Abrantes, None; M.E. Farah, None; J.A. Cardillo, None; R.A. Costa, None.
Investigative Ophthalmology & Visual Science December 2002, Vol.43, 4424. doi:
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      M Skaf, PP Bonomo, ML Abrantes, ME Farah, JA Cardillo, RA Costa; Intravitreal Triamcinolone Versus Thermodynamic Therapy for Treatment of Choroidal Neovascularization Associated With Retinal Pigment Epithelial Detachment . Invest. Ophthalmol. Vis. Sci. 2002;43(13):4424.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: To compare the use of intravitreal triamcinolone acetonide (TA) and low irradiance 810-nm light coupled to intravenous injection of small-volume, high-concentration indocyanine green (ICG) bolus, termed Thermodynamic Therapy (TDT), for treatment of choroidal neovascularization associated with retinal pigment epithelial detachment (PED) in age-related macular degeneration (AMD). Methods: A small consecutive series of eyes initially treated with TDT (n = 3) were compared with a selected group of eyes treated with intravitreal injection of 4 mg of TA (n = 2) with similar lesion features. In each eye, ophthalmic examination, fluorescein and indocyanine green angiography as well as optical coherence tomography (OCT) were performed. A minimum follow-up of 4 months was obtained. Results: By 2 weeks after treatment, the PED had flattened completely (n = 3) or partially (n = 2) in all eyes. For the eyes in which the intravitreal TA was used, hyperfluorescent areas within the PED previously identified as «hot spots» on ICG angiography were still detected after 1 month of treatment despite PED resolution. On the contrary, these hyperfluorescent areas in the eyes treated with TDT gradually became hypofluorescent or similar to the background level of choroidal fluorescence at 1 month follow-up visit. At 4 months post treatment, four eyes had improved by 2 or more ETDRS lines of visual acuity and one eye (TDT) remained unchanged from the initial visual acuity. No complications related to treatments were found. Conclusion: Both TDT and intravitreal injection of TA achieved short-term visual acuity stabilization or improvement in all eyes of AMD patients with CNV and PED. These findings were consistent with gradual retinal architecture restoration observed in optical coherence tomograms during the follow-up period.

Keywords: 308 age-related macular degeneration • 346 choroid: neovascularization • 454 laser 
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