Abstract
Abstract: :
Purpose: To determine the antibiotic susceptibility patternof coagulase-negative staphylococci (CNS) in patients undergoinganterior segment intraocular surgery.Methods: Conjunctivalcultures were obtained (prior to application of antibiotic orantiseptic agent) from 66 consecutive patients undergoing intraocularsurgery who consented to this prospective study. All bacteriaisolates were identified and antibiotic susceptibility determinedby Kirby-Bauer disc-diffusion technique.Results: A total of76 CNS were isolated. ABX, antibiotic;S, Sensitive; I, Intermediate; R, Resistant; PCN, penicillin;OX, oxacillin; MET, methicillin; MZ, mezlocillin; CZ, cefazolin;CTX, cefotaxime; CAZ, cetazidime; Cipro, ciprofloxacin; Levo,levofloxacin; Nor, norfloxacin; Oflox, ofloxacin; IPM, imipenem;MER, meropenem; Gent, gentamicin; Tobra, tobramycin; Amik, amikacin;Neo, Neomycin; Eryth, erythromycin; TCN, tetracycline; C, chloramphenicol;Vanco, vancomycin.Conclusions: Coagulase-negative staphylococciisolated from patients undergoing intraocular surgery remainhighly sensitive to all antibiotics tested except for penicillinanalogues, ceftazidime, and erythromycin. This study suggeststhat fluoroquinolones and aminoglycosides are effective prophylacticantibiotics against most coagulase-negative staphylococci. Support:Edward E. Hills Fund, Department of Ophthalmology, Universityof LMU, Munich, Germany, and Hannelore-Georg Zimmerman Foundation,Munich, Germany.
Keywords: 319 antibiotics/antifungals/antiparasitics • 398 endophthalmitis • 365 conjunctiva