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RW Snyder, T Krueger, DE Nix; Kill Curves for Vancomycin versus 3rd Generation Quinolones . Invest. Ophthalmol. Vis. Sci. 2002;43(13):4452.
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Purpose: Intracameral antibiotics have been advocated for the prevention of post-cataract endophthalmitis. To be effective, an antibiotic must be fast acting. We compared kill curves of ocular isolates with vancomycin and third generation quinolones. Methods: The MIC's were determined for 15 coagulase-negative Staphylococcus sp and S. aureus isolates. Kill curves were performed at 8-16 x MIC, 2-4 x MIC, and 0.5-1 x MIC over 8 hours with counts at time 0, 2h, 4h and 8h. Results: The MIC's ranged from 0.06-2 µg/ml for vancomycin, moxiflocaxin and gatifloxacin. Moxifloxacin killed at least 3 logs after 8h for both organisms. The quinolones showed dose dependent killing while the extent of killing did not correlate with the vancomycin concentration relative to the MIC of the organism as long as concentration was ≷ 2-4 µg/ml. Conclusion: A third generation quinolone is more suitable for killing bacterial seeded into the anterior chamber than vancomycin.
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