December 2002
Volume 43, Issue 13
ARVO Annual Meeting Abstract  |   December 2002
Kill Curves for Vancomycin versus 3rd Generation Quinolones
Author Affiliations & Notes
  • RW Snyder
    Department of Ophthalmology
    University of Arizona Tucson AZ
  • T Krueger
    Pharmacy Practice & Science
    University of Arizona Tucson AZ
  • DE Nix
    Pharmacy Practice & Science
    University of Arizona Tucson AZ
  • Footnotes
    Commercial Relationships    R.W. Snyder, Allergan F, R; T. Krueger, None; D.E. Nix, None. Grant Identification: Support: Research to Prevent Blindness
Investigative Ophthalmology & Visual Science December 2002, Vol.43, 4452. doi:
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    • Get Citation

      RW Snyder, T Krueger, DE Nix; Kill Curves for Vancomycin versus 3rd Generation Quinolones . Invest. Ophthalmol. Vis. Sci. 2002;43(13):4452.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract: : Purpose: Intracameral antibiotics have been advocated for the prevention of post-cataract endophthalmitis. To be effective, an antibiotic must be fast acting. We compared kill curves of ocular isolates with vancomycin and third generation quinolones. Methods: The MIC's were determined for 15 coagulase-negative Staphylococcus sp and S. aureus isolates. Kill curves were performed at 8-16 x MIC, 2-4 x MIC, and 0.5-1 x MIC over 8 hours with counts at time 0, 2h, 4h and 8h. Results: The MIC's ranged from 0.06-2 µg/ml for vancomycin, moxiflocaxin and gatifloxacin. Moxifloxacin killed at least 3 logs after 8h for both organisms. The quinolones showed dose dependent killing while the extent of killing did not correlate with the vancomycin concentration relative to the MIC of the organism as long as concentration was 2-4 µg/ml. Conclusion: A third generation quinolone is more suitable for killing bacterial seeded into the anterior chamber than vancomycin.

Keywords: 398 endophthalmitis 

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