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A Alcala-Delgadillo, L Niño de Rivera, F Graue-Wiechers; Retinal Prosthesis: An Electronic Model . Invest. Ophthalmol. Vis. Sci. 2002;43(13):4464.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose:To design an electronic model, using neural networks and microprocessing technology CMOS, for building a retinal prosthesis for intraocular estimulation at RPE. Methods:We designed a silicon retinal microchip; 4mm in diameter, with microholes in the XII,III, VI and IX meridians with microbrushing in the internal fase of 10 microns of diameter each. In the external fase it has a capacity for 10x10 pixels with microphotodiodes. In vitro implantation over retinal mouse slices and electrophysiology observation was made. Results:We were able to obtain a silicon electronic model with terminals in microbrushing form that can touch directly the SPE. With a control light estimulation over the external fase of silicon chip, we obtain a 70% electrophysiology global response in relation to the expected in experimental models of retinal mouse slices. Conclusion:This electronic model for retinal prosthesis with direct celular estimulation produce an augmentation of the electrophysiology response in the RPE
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