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HW Flynn, IU Scott, TG Murray, WJ Feuer, J Schiffman; Outcomes of Surgery for Retinal Detachment Associated with Proliferative Vitreoretinopathy Using Perfluoro-n-octane: A Multicenter Study . Invest. Ophthalmol. Vis. Sci. 2002;43(13):4504.
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Purpose: To report visual acuity and anatomic outcomes, as well as complications, of management of retinal detachment (RD) with proliferative vitreoretinopathy (PVR) using intraoperative perfluoro-n-octane (PFO), and to investigate clinical features associated with anatomic and visual acuity outcomes. Methods: A prospective, noncomparative, observational, multicenter study including patients ≷15 months of age who underwent management of RD associated with PVR with intraoperative PFO at 24 study sites. Outcome measures included visual acuity and rates of retinal reattachment, reoperation, retained PFO, corneal edema, elevated intraocular pressure (IOP ≷25 mm Hg), hypotony, (IOP <5 mm Hg), and cataract. All outcome measures were assessed at 1 day, 1 week, 1 month, 3 months, and 6 months postoperatively and at the last examination. Results: The study included 555 eyes of 555 patients followed a median of 5.6 months. Visual acuity ≷20/200 was measured in 51 (10%) patients preoperatively and 85 (24%) at 6 months. Postoperative visual acuity improved in 274 (60%) eyes, remained stable in 106 (23%), and worsened in 85 (18%) eyes. Of the 300 patients with visual acuity 20/200 at 6 months postoperatively. Six-month follow-up data was obtained for 356 (65%) eyes; the retina was attached in 279 (78%) eyes and retained PFO was noted in 20 (6%). Throughout follow-up, 238 (43%) eyes underwent reoperation for recurrent RD. At 6 months, corneal edema, elevated IOP, and hypotony were noted in 26 (7%), 6 (2%), and 48 (15%) eyes, respectively. Conclusion: Retinal reattachment and preserved visual acuity were achieved in most eyes which underwent management of RD associated with PVR with intraoperative PFO.
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