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X He, X Mai; Clinical Reports on Levodopa Administration in Amblyopia . Invest. Ophthalmol. Vis. Sci. 2002;43(13):4699.
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Purpose: To investigate the effect of oral administration of levodopa on childhood amblyopia. Methods: 46 childhood patients (81 eyes) with amblyopia were randomly distributed into groups A, B. Group A patients (31 patients,54 eyes, visual acuity 0.1-0.7) received 125 or 250mg of Siliba (levodopa without carboxylase inhibitor) alone,twice a day for 3 months. Group B (15 patients,27 eyes, visual acuity 0.1-0.7) received treatment of visual physiological stimulator.Visual acuity were recorded before treatment and after the completion of treatment. P-VEP was recorded in 30 eyes each group. Results: 85% eyes had an improvement in visual acuity (2-8 lines, average 5 lines) after treatment in Group A. Fifteen patients (16 eyes) had an improved visual acuity of 1.0. P-VEP showed the significant shortening of P100 latency and increase of P100 amplitude(p<0.05).Compared with the results of Group B (87% effective in improvment of visual acuity 2-8 lines, average 6 lines), the effect is similar (p≷0.05). Conclusion: The oral administration of levodopa can enhance vision in amblyopia, similar to the result of visual physiological stimulator. Levadopa can be an effective alternative in treating amblyopia.
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