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AC James; The Pattern Pulse Multifocal Visual Evoked Potential . Invest. Ophthalmol. Vis. Sci. 2002;43(13):4742.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: To define the pattern pulse multifocal visual evoked potential (PP-mVEP), and determine its characteristics in a sample of normal subjects, in terms of amplitude of response attainable, the variation in waveform across visual field, distributions of potential over the scalp, and compare pattern pulse with contrast-reversing multifocal stimuli. Methods: Dichoptic visual evoked potentials were obtained by concurrently stimulating each eye independently with 60 regions of a cortically-scaled dartboard with pulses of pattern contrast. Responses were recorded from 12 normal subjects, using a 32 channel Neuroscan system, and kernels relating responses to each region were estimated. Results: Response waveform sets varied in maximum amplitude from 1.8 to 6.8 uV. The largest responses for all subjects occurred on electrode POz against average reference. In a direct comparison with a contrast-reversing multifocal analysis, the pattern pulse responses had similar waveforms and topography, but were 15 times larger in amplitude. An RMS signal to noise improvement of 1.8 times for pattern pulse versus contrast reversal equates to a reduction in recording time of 70 percent. Conclusion: The pattern pulse multifocal visual evoked potential can simultaneously characterize 60 regions of the visual field for both eyes in around 7 minutes of recording time.
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