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Juan Mei Zhang, Jian Feng Wu, Jian Hua Chen, Ling Wang, Tai Liang Lu, Wei Sun, Yuan Yuan Hu, Wen Jun Jiang, Da Dong Guo, Xing Rong Wang, Hong Sheng Bi, Jost B. Jonas; Macular Choroidal Thickness in Children: The Shandong Children Eye Study. Invest. Ophthalmol. Vis. Sci. 2015;56(13):7646-7652. doi: https://doi.org/10.1167/iovs.15-17137.
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© ARVO (1962-2015); The Authors (2016-present)
To examine the thickness of the macular choroid and its associations in school children aged 6 to 18 years.
The school-based cross-sectional Shandong Children Eye Study included 6026 (94.7%) of 6364 eligible children fulfilling the inclusion criterion of an age from 4 to 18 years. Spectral-domain optical coherence tomography (SD-OCT) was performed for a subgroup of 972 school children aged 6+ years. All participants underwent ocular examinations, including measurement of visual acuity, cycloplegic refractometry, biometry, and SD-OCT (enhanced depth imaging mode) for measurement of choroidal thickness.
The study included 972 children (501 girls) with a mean age of 11.3 ± 3.3 years (range, 6–18 years) and mean axial length of 24.10 ± 1.56 mm (range, 16.57–28.82 mm). Mean choroidal thickness was thicker (P < 0.001) at 500 μm temporal to the foveola (290 ± 67 μm) than in the subfoveal region (283 ± 67 μm; range, 113–507 μm) and the region 500 μm superior to the fovea (283 ± 66 μm), where it was thicker (P < 0.001) than at 500 μm inferior of the foveola (281 ± 66 μm), and it was thinnest (P < 0.001) at 500 μm nasal of the foveola (268 ± 67 μm). In multivariate analysis, thicker SFCT was (overall correlation coefficient r: 0.51) associated with shorter axial length (P < 0.001; standardized correlation coefficient β: −0.48; B: −23.7; 95% confidence interval [CI]: −27.2 to −20.3), male sex (P = 0.006; β: −0.08; B: −10.7; 95% CI: −18.3 to −3.11), and younger age (P = 0.04; β: −0.07; B: −1.46; 95% CI: −2.85 to −0.07).
As in adults, thicker SFCT in children and teenagers was markedly associated with shorter axial length, and to a lesser degree with male sex and older age. As in adults, increasing axial myopia in teenagers is associated with choroidal thinning and development of a leptochoroid.
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