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Yuri Fujino, Takehiro Yamashita, Hiroshi Murata, Ryo Asaoka; Adjusting Circumpapillary Retinal Nerve Fiber Layer Profile Using Retinal Artery Position Improves the Structure–Function Relationship in Glaucoma. Invest. Ophthalmol. Vis. Sci. 2016;57(7):3152-3158. doi: https://doi.org/10.1167/iovs.16-19461.
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© ARVO (1962-2015); The Authors (2016-present)
To investigate whether correcting the circumpapillary retinal nerve fiber layer (cpRNFL) thickness profile, using retinal artery position and papillomacular bundle tilt, can improve the structure–function relationship in glaucoma patients.
Spectral-domain optical coherence tomography (SD-OCT) and visual field measurements were conducted in 142 eyes of 90 subjects with open angle glaucoma. The SD-OCT cpRNFL thickness profile was corrected for retinal artery position and/or papillomacular tilt in all twelve 30° sectors of the optic disc, and the structure–function relationship against corresponding 30° sectorial retinal sensitivity was investigated by using linear mixed model.
Applying a correction to the cpRNFL thickness profile for retinal artery position resulted in a stronger structure–function relationship in all 12 sectors of the optic disc. Furthermore, applying a further adjustment for papillomacular tilt resulted in a further improvement in 9 of 12 sectors.
Correcting cpRNFL profile, using the retinal artery position significantly strengthened the structure–function relationship. In most optic disc sectors, using the papillomacular bundle tilt improved cpRNFL thickness measurements.
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