Experimental glaucoma eye
Acute Compliance (
left) exceeds Control eye
Acute Compliance (
right) in the animal that demonstrates the greatest Control eye
Acute Compliance (Monkey 8). Delineated structures within the IOP 10 (
A,
F) and IOP 30 mm Hg (
B,
G) OCT data sets of the EG (
left) and control (
right) eyes of Monkey 8.
Insets in these panels are en face views of the delineated BMO and ALCS points of each data set. In (
C) and (
H) the IOP 10 and IOP 30 OCT data sets have been overlaid by anchoring them to their shared BMO reference plane shown in
red. In (
D) and (
I), the same IOP 10 and IOP 30 OCT data sets have been overlaid by anchoring them to their shared BM reference plane shown in
blue. Note that posterior deformation of the IOP 30 ALCS (
yellow dots) is present relative to the IOP 10 ALCS (
off-white dots) in (
C), and this deformation is larger in (
D) because it also includes posterior deformation of BM relative to its reference plane (
blue line). No adjustments to
z-axis magnification have been made to these images. Magnified views of (
D) and (
I) are shown in (
E) and (
J) absent the ILM (
green) so as to make the laminar and peripapillary scleral deformation components more apparent. Structures shown are ILM (
green), BM (
orange), BMO (
red points), and ALCS (
yellow points). To differentiate the structures in the overlaid images, the colors at 10 mm Hg have been washed out. The control eye of this animal demonstrated the largest control eye
Acute Compliance change in the OCT connective tissue parameters
BMOD-BM,
ALCSD-BM, and
ALCSD-BM. It therefore set the upper range of control eye
Acute Compliance used for the definition of EG eye hypercompliance (−59.0 μm, −90.1 μm, and −32.0 μm, respectively, see
Supplementary Table S2 and Methods). The EG eye of this animal demonstrates substantial hypercompliance for the same three parameters (−82.0 μm, −140.5 μm, and −58.6 μm, respectively). The distinction between
ALCSD-BM (which captures both peripapillary scleral and laminar deformation, relative to peripheral BM) and
ALCSD-BMO (which captures laminar deformation relative to BMO, alone) can be clearly seen for both eyes by overlaying the IOP 10 and IOP 30 data sets using the BMO reference plane (in [
C] and [
H]) or by overlapping the IOP 10 and IOP 30 data sets using the BM reference plane (in [
D] and [
I]).