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Zaid Mammo, Morgan Heisler, Chandra Bala, Sieun Lee, Paul MacKenzie, Steven Schendel, Andrew Merkur, Eduardo Navajas, William Huxley Morgan, Marinko Venci Sarunic; Quantitative Speckle-variance Optical Coherence Tomography of Radial Periparpillary Capillaries in Glaucoma. Invest. Ophthalmol. Vis. Sci. 2016;57(12):No Pagination Specified. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
To demonstrate the utility of speckle-variance Optical Coherence Tomography (svOCT) in imaging the Radial Peripapillary Capillaries (RPC) and assessing their role as a vascular parameter of glaucoma damage.
Thirty two eyes from 17 subjects were imaged with svOCT (1060-nm, 100-kHz custom built-system). Unilateral glaucoma subjects (Group A): 5 subjects (10 eyes), glaucoma suspects (Group B): 3 subjects (6 eyes); Normal subjects (Group C): 9 subjects (16 eyes). Automated 30-2 Humphrey Visual Field (HVF), optic disc photos, spectral-domain OCT (SD-OCT) and svOCT peripapillary imaging were done for Groups A and B. For group A, the imaged region was chosen based on the combination of focal optic nerve damage and corresponding HVF loss, the same region in the fellow eye was imaged. For group B, the peripapillary area with retinal nerve fiber layer (RNFL) thinning and normal HVF were imaged with svOCT. All peripapillary areas were imaged in Group C. Manual tracing was used to quantify the RPC density. Mean capillary density (CD) was compared across different groups. Correlations between CD, RNFL thickness, and Visual Field Index (VFI) values were explored.
The CD per imaged area in the glaucomatous eye of Group A (0.09+/-0.05) was significantly lower than the fellow eye in Group A (0.30+/-0.06), Group B (0.28+/-0.01) and Group C (0.33+/-0.04) (P<0.001), no other statistically significant differences were found otherwise. Overall, a statistically significant correlation was found between CD and RNFL thickness (Slope=0.0010, p<0.0001). A statistically significant correlation was found between CD and VFI (Slope=0.0056, p=0.0012).
Using svOCT, reduced RPC density was noted in subjects with glaucomatous optic neuropathy. The CD showed strong correlation with VFI and RNFL thickness. Quantitative svOCT could be an adjunct modality in the evaluation of glaucoma patients.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
Optic nerves of subject with left-sided glaucoma (Right=A and Left=B). Preserved visual field function is noted in the right eye (C) with significant loss is noted in the left eye (D). On svOCT, preserved RPCs capillaries are noted in the right eye (F) with significant loss is found in the left eye (H). The Outer Plexiform/Inner Nuclear Layer (OPL/INL) capillaries are preserved in both eyes (G&I)
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