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Serena Colard, Monique Cordonnier, Martina Maria Delle Fave, Cameron Parsa; Prevalence of physiological anisocoria and influence of iris corneal parameters a in an adult population. Invest. Ophthalmol. Vis. Sci. 2016;57(12):4560.
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© ARVO (1962-2015); The Authors (2016-present)
Estimate prevalence of physiological anisocoria among adult population. Establish asymmetry of the corneal diameter and/or a difference of the iris thickness in the same population
Monocentric prospective study. Ethical committee approval has been granted, all patient signed a consent form. 250 consecutive patient aged over 18 were included. All underwent 2WIN photo in dim light to establish pupillary diameter (PD). 25th patients presenting PD difference <0,4 mm or > or = 0,4 underwent slit lamp (SL) examination white-to-white (WTW) horizontal and vertical and acOCT to evaluate iris thickness PD and WTW. Anisocoric underwent 2WIN photograph in bright light. Patients with PD difference > in dark light received cocaine drop 10 % /eye and a second photograph after 30 minute. Midriatic effect was observed; difference <1 mm in the diameter were graded as physiological anisocoria. Patients presenting none or mild midriatic effect received a third drop and photo after 30 more minutes: PD < 1mmwere graded as physiological anisocoria; PD >1 mm Claude Bernard Horner pupil. III nerve palsy, Adie pupil or a pharmacological anisocoria have been rule out with SL and eye motility examination.
31 patients were diagnosed with physiological anisocoria. No significative difference was noted among age, iris colour, spherical equivalent although there was more females with anisocoria (p<0,054). In anisocric patient no significative difference was noted for WTW horizontal (SL and OCT) (p>0,05); vertical WTW p<0,026. In the 2 pupils of control group we observe positive correlation between pupillary diameter and iris thickness. Negative correlation was observed between age and pupillary diameter and spherical equivalent. No correlation between pupillary diameter and WTW. For the Anisocoria group big and small pupil negative correlation between pupillary diameter and age as well as pupillary diameter and WTW measured with OCT. Small pupil of anisocoria group showed positive correlation between pupillary diameter measured at OCT and iris thickness in the temporal quadrant alone and iris thickness of nasal + temporal quadrants.
Prevalence of physiological anisocoria is 12,4% or one in eight people among adults. Elderly people have smaller pupils, myops have bigger pupil. Iris is ticker when pupils are bigger. No asymmetry of the corneal diameters or the iris tickness between individual presenting anisocoria.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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