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Kazuhiko Mori, Junta Kubo, Rie Oda, Yoko Ikeda, Morio Ueno, Kojiro Imai, Haruna Yoshikawa, Yuji Yamamoto, Noriko Koizumi, Shigeru Kinoshita, Chie Sotozono; Quantitative analysis of the lens position and the curvature of the anterior lens surface in normal Japanese subjects. Invest. Ophthalmol. Vis. Sci. 2016;57(12):5135. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
Various factors, including lens position and shape, jointly involve acute angle closure. Lens vault (LV) is one of the indicators to quantify the lens position, while others which quantify the curvature of the anterior lens surface have yet to be fully elucidated. The purpose of this study was to develop a new indicator to quantify the lens surface shape, and to reveal its association with other ocular features.
This study involved 188 eyes of 94 normal Japanese subjects (26 males and 68 females; mean age: 67.2±5.9 years). Inclusion criteria included subjects who 1) visited the outpatient clinic of Kyoto Prefectural University of Medicine, Kyoto, Japan between June 2014 and April 2015, 2) were diagnosed by glaucoma specialists as normal based on several ophthalmic examinations, and 3) in whom reliable horizontal images could be obtained using anterior segment optical coherence tomography (AS-OCT) (SS-1000 CASIA; Tomey Corp.). In all eyes, AS-OCT images were imported to image processing software (Image J 1.48q; NIH). The line connecting the scleral spur (SS) was regarded as the SS-baseline, and anterior chamber depth (ACD), width (ACW), and LV were defined as described (Nongpiur ME, 2011). The perpendicular distance at the point of 2mm apart from visual axis, from the anterior lens surface to the horizontal line at the anterior pole parallel to the SS-baseline were defined as nasal and temporal lens protrusion distance (LPDn and LPDt, respectively). When the pupillary diameter was less than 4mm, those cases in which the anterior capsular position beneath the iris could not be clearly detected were excluded. The clinical features of age, sex, refractive error (RE), corneal radius (CR), and axial length (AL) were also measured. Step-wise multiple regression analysis was performed, regarding LPD or LV as an objective value, and age, sex, RE, CR, AL, ACD, and ACW as explanatory variables.
Statistical differences were found between LPDn and LPDt on either eye (Wilcoxon signed-rank test, p<0.05). LPD and LV were found to be independent, and LV was correlated with age, ACD, ACW, and CR. Step-wise multiple regression analysis showed that ACD (p<0.001) and CR (p=0.02) were significant explanatory variables for LPD.
LPD in the normal Japanese subjects was not completely symmetrical, but was related to CR and ACD.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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