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Jian Yu; Evaluation Of Retinal Perfusion And Structure In Patients With Obstructive Sleep Apnea Syndrome : An Optical Coherence Tomography Angiography Study. Invest. Ophthalmol. Vis. Sci. 2016;57(12):5468. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
Previous studies have reported that patients with obstructive sleep apnea syndrome(OSAS) had a high incidence of glaucoma and anterior ischemic optic neuropathy,microvascular dysfunction has been proposed as a potential mechanism.The purpose of the study was to investigate the retinal perfusion and retinal thickness in patient with OSAS.
88 OSAS patients were included in the study and further divided into mild, moderate,severe and severe + hypertension groups. All the patient did not have any other systemic disease except for the severe + hypertension group,and the blood pressure of the severe +hypertension group were well controled. The peripapillary retinal nerve fiber layer (RNFL) thickness and peripapillary flow density measurements of the subjects were obtained using aigiography optical coherence tomography(RTVue-XR Avanti; Optovue, Fremont, CA, USA),The peripapillary flow density and RNFL thickness measurements were compared among the 4 groups.
The mean age,IOP,AXL, and BMI was not significantly different among the 4 groups,The mean systolic blood pressure were greater in the severe + hypertension group than mild group.Compared to moderate and severe group,the peripapillary flow density in mild group were significant greater,But there were not any difference of RNFL thickness between mild and severe + hypertension group.In addition,we did not found any difference of peripapillary flow density and RNFL between mild and severe + hypertension groups.
OSAS patients had retinal perfusion alterations that may have significance on the pathophysiology of the ophthalmic disorders associated with OSAS.Control of the systolic blood pressure maybe beneficial for OSAS patient with hypertensition.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
Figure 1. The box plots represent the SBP of 4 groups
Figure 2. The box plots represent the peripapillary flow density in 4 groups. The statistical differences between groups were calculated using one-way analysis of variance followed by the Bonferroni–Dunn post hoc test.
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