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Takeo Fukuchi, Shun Ochiai, Yuta Sakaue, Tetsuya Togano, Aki Suetake, Ryoko Igarashi; Measurements of the Inner Macular Thickness As an Indicator to Evaluate Foveal Visual Function in Open-angle Glaucoma.. Invest. Ophthalmol. Vis. Sci. 2016;57(12):371.
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© ARVO (1962-2015); The Authors (2016-present)
To investigate whether measurements of the inner macular thickness can indicate foveal visual function in open-angle glaucoma (OAG).
Sixty-two eyes from 62 OAG patients (mean age; 56.2±10.2 yr-old and mean MD value of HFA24-2; -14.23±8.08dB) were included into the study. The macular region was separated into 5 areas corresponded to the clusters of HFA10-2 test points (Figure 1). The thickness of the retinal nerve fiber layer (RNFL), ganglion cell layer(GCL)+inner plexiform layer (IPL) and RNFL+GCL+IPL (GCC) in each 5 area were measured with retinal ganglion cell displacement by a SD-OCT (3D OCT-2000, Topcon, Tokyo, Japan). And then we evaluated the correlation between the thickness in each area and foveal sensitivity threshold.
In the central area 1, the RNFL, GCL+IPL as well as GCC were strongly correlated with foveal sensitivity threshold (R=0.711, 0.725, and 0.748, respectively, p<0.001). The upper arcuate area 2 and the lower arcuate area 4 associated weak to moderate correlations between the RNFL, GCC and foveal sensitivity threshold (R=0.338 to 0.440, P<0.01). No statistical correlations were detectable in the most peripheral areas 3 and 5.
Measurements of the RNFL, GCL+IPL, and GCC particularly in the central area 1, just corresponded to the papillo-macular bundles, might be an indicator to evaluate foveal visual functions including sensitivity threshold and possibly visual acuity in OAG.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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