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Nelise de Paiva Lucena, Kaline Sandrelli Alves Ferreira, Bruna Marília Alves dos Santos, Maria Isabel Lynch, Rodrigo Pessoa Cavalcanti Lira; Is intracameral moxifloxacin a safe option for prevention of post cataract endophthalmitis?. Invest. Ophthalmol. Vis. Sci. 2016;57(12):5403.
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© ARVO (1962-2015); The Authors (2016-present)
Intracameral moxifloxacin (MFLX) have been used worldwide as an off-label option for prevention of post cataract endophthalmitis. There are some concerns related to long-term safety. The purpose of this research was to study the 2-years safety of intracameral MFLX.
A retrospective survey included the last 100 surgeries before (control group) and the first 100 surgeries after the introduction of intracameral MFLX for prevention of post cataract endophthalmitis (MFLX group) at our hospital in April 2013 (200 eyes of 200 patients). The inclusion criteria were: patients with indication of cataract surgery, ≥ 60 years old, and without history of allergy to quinolones. It was excluded patients with any other ocular disease than cataract (glaucoma, retinal disease, trauma, cornea dystrophy, etc.). The same surgeon performed all surgeries. The operative technique was phacoemulsification (Infiniti®, Alcon®) with intraocular lens implantation (Sensar® AR40e, Abbott®). The MFLX group received moxifloxacin (150-μg/0.03 ml) at the end of the surgery. The records of 2-years follow up were reviewed. The main outcomes were (preoperative and 2-years follow up) corneal endothelial cell density (EM935®, Haag-Streit®), corneal pachymetry (Ocuscan®, Alcon®), best-corrected visual acuity and intraocular pressure. Written consent was obtained from each patient. The institutional research ethics committee approved the study. Between-group differences for two groups continuous variables were compared using the Mann-Whitney U-test. Gender was compared using the Chi-square test.
There was no statistical difference between groups in gender distribution, mean age, corneal endothelial cell density, corneal pachymetry, best-corrected visual acuity and intraocular pressure (Table 1). No adverse events or endophthalmitis were observed.
The results suggest MFLX is a safe option for prevention of post cataract endophthalmitis.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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