September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Spectral-Domain Optical Coherence Tomography Findings in Peters'Anomaly infants
Author Affiliations & Notes
  • Jiaxu Hong
    Ophthalmology, Eye & Ear, Nose, Throat Hospital, Shanghai, China
  • Xinghuai Sun
    Ophthalmology, Eye & Ear, Nose, Throat Hospital, Shanghai, China
  • Reza Dana
    Harvard Medical School, Boston, Massachusetts, United States
  • JianJiang Xu
    Ophthalmology, Eye & Ear, Nose, Throat Hospital, Shanghai, China
  • Footnotes
    Commercial Relationships   Jiaxu Hong, None; Xinghuai Sun, None; Reza Dana, None; JianJiang Xu, None
  • Footnotes
    Support   the National Natural Science Foundation of China (81170817, 81200658, 81300735, 81270978, U1205025, and 81330022)
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4256. doi:
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      Jiaxu Hong, Xinghuai Sun, Reza Dana, JianJiang Xu; Spectral-Domain Optical Coherence Tomography Findings in Peters'Anomaly infants. Invest. Ophthalmol. Vis. Sci. 2016;57(12):4256.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose : To present in vivo anterior segment optical coherence tomography (OCT) findings in Peters' anomaly infants, and eveluate their impact on surgical decision-making.

Methods : This is a single-center, consecutive, retrospective, observational case series. Forty-four eyes of 27 Peters’ anomaly infants (5–18 months) underwent keratoplasty between January 2012 and September 2014. Medical records of patients were reviewed retrospectively. Demographics, ocular findings, comorbidity, and histopathological data were analyzed. Eyes were imaged using spectral-domain optical coherence tomography (SD-OCT) under general anesthesia before corneal transplantation.

Results : Among the 27 patients, 10 patients had unilateral disease, and 17 patients had bilateral disease. There was a male predominance in the study group (74.1%). Two patients with mild disease (3 eyes) had a posterior corneal defect with leukoma (2/27, 7.4%). Twenty patients (32 eyes) with iridocorneal adhesions were classified as having moderate Peters’ anomaly (20/27, 74.1%), and 5 patients (9 eyes) with lenticulocorneal adhesions were classified as having severe Peters’ anomaly (5/27, 18.5%). SD-OCT revealed that the median value of the central corneal thickness was 585μm, 567μm, and 700μm in mild, moderate, and severe patients, respectively (P = 0.016). There was no statistically significant difference in iridocorneal adhesions range among three groups (P = 0.083). However, the range of angle closure (P < 0.001) was significantly different among the groups, indicating it might serve as a novel OCT parameter for assessing the severity of Peter’s anomaly. SD-OCT altered the understanding of the anatomical structure of the anterior chamber and surgical approach in seven patients from 33 keratoplasties and/or combined surgeries (21.2%).

Conclusions : Our study showed that the information gained from SD-OCT allows classifying the type and severity of Peters’ anomaly and and is useful for surgical decision-making.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.



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