Wide-field MultiColor Spectral Imaging and Wide-field Spectral Domain Optical Coherence Tomography Imaging in Retinitis Pigmentosa

Abstract

Purpose : To evaluate the diagnostic value of wide-field MultiColor spectral imaging (WF-MC) and wide-field spectral domain optical coherence tomography (WF-SD-OCT) in patients with retinitis pigmentosa.

Methods : Between November 2014 and November 2015 a consecutive series of 42 patients with retinitis pigmentosa were examined clinically and with WF-MC and WF-SD-OCT (55 degrees, Spectralis MultiColor HRA & OCT, Heidelberg Engineering, Germany)). Further retinal imaging in 30 or 55 degree mode (fundus autofluorescence (FAF), near-infrared autofluorescence (NIA), spectral domain OCT (SD-OCT) were performed with the same system. DNA testing was performed via targeted gene panel diagnostics.

Results : The series of patients included retinitis pigmentosa associated with different disease genes and different inheritance patterns. WF-MC provided a wide-angle view of retinal abnormalities beyond the vascular arcades excluding the far periphery. The evaluation of the three different monochromatic images (blue 486 nm, green 518 nm, near-infrared 815 nm) allowed a differentiation in inner retinal or pigment epithelial and choroidal lesions. Retinal thinning beyond the posterior pole can be visualized with WF-SD-OCT with a good correlation to choroidal thinning within the same image.

Conclusions : WF-MC and WF-SD-OCT provide the opportunity to observe more details of retinal alterations in retinitis pigmentosa in the midperipheral and peripheral retina area.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.