Purchase this article with an account.
Simone Kellner, Silke Weinitz, Ghazaleh Farmand, Heidi Barbara Stoehr, Bernhard HF Weber, Ulrich Kellner; Wide-field MultiColor Spectral Imaging and Wide-field Spectral Domain Optical Coherence Tomography Imaging in ABCA4-related retinal dystrophies. Invest. Ophthalmol. Vis. Sci. 2016;57(12):147. doi: https://doi.org/.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
To evaluate the diagnostic value of wide-field MultiColor spectral imaging (WF-MC) and wide-field spectral domain optical coherence tomography (WF-SD-OCT) in patients with ABCA4-related retinal dystrophies.
Between November 2014 and November 2015 a consecutive series of 23 patients with ABCA4-related retinal dystrophies were examined clinically and with WF-MC and WF-SD-OCT (55 degrees, Spectralis MultiColor HRA & OCT, Heidelberg Engineering, Germany)). Further retinal imaging in 30 or 55 degree mode (fundus autofluorescence (FAF), near-infrared autofluorescence (NIA), spectral domain OCT (SD-OCT) were performed with the same system. DNA testing was performed via targeted gene panel diagnostics.
The series of patients included ABCA4-related retinal dystrophies. WF-MC provided a wide-angle view of retinal abnormalities beyond the vascular arcades excluding the far periphery. In the majority of patients lesions were confined to the posterior pole, mid-peripheral lesions indicated progression from macular dystrophy to cone-rod dystrophy. The evaluation of the three different monochromatic images (blue 486 nm, green 518 nm, near-infrared 815 nm) allowed a differentiation in inner retinal or pigment epithelial and choroidal lesions. Subretinal lesions beyond the posterior pole could be visualized with WF-SD-OCT as indicator for cone-rod-dystophy.
WF-MC and WF-SD-OCT provide the opportunity to observe more details of retinal alterations in ABCA4-related retinal dystrophies at the posterior pole and in the peripheral retina visualizing the continuous change of lesions from the fovea to the periphery
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
This PDF is available to Subscribers Only