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Céline Mebsout Pallado, Anne Sikorav, Oudy Semoun, Camille JUNG, Eric H Souied; Progression of macular atrophy in pattern dystrophies.. Invest. Ophthalmol. Vis. Sci. 2016;57(12):163. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
To quantify the progression of macular atrophy associated with pattern dystrophies using a novel fundus autofluorescence semi-automated software and to analyze demographical and clinical data.
Patients diagnosed with pattern dystrophy followed in the retina department of a single academic medical center during at least 2 years were included in this retrospective, observational study if they had macular atrophy. Best-corrected visual acuity (BCVA), fundus photographs, infrared reflectance, fundus autofluorescence (FAF) imaging, and spectral-domain optical coherence tomography were routinely performed associated with fluorescein and indocyanine green angiographies when necessary. The progression of macular atrophy areas was evaluated on FAF frames using Region Finder Analyser®, a semi automated software embedded in Spectralis device.
We included 19 eyes of 12 patients. The median follow-up was 4.5 years [Interquartile Range IQR 2.7 – 5.5]. 15.8% of affected eyes (3/19) presented with choroidal neovascularization. Median initial BCVA was 0.2 logMAR [IQR 0.05 – 0.4]. Median final BCVA was 0.2 logMAR [IQR 0.1-0.4]. Decreased vision occurred in 15.8% of cases (3/19). Atrophy involved foveal area in 68.4% of cases. The median atrophy progression rate evaluated by Region Finder Analyser® was 0.101mm2/year [IQR 0.054 – 0.257]. The median initial atrophy area was 0.294mm2 [IQR 0.18 – 0.398], and the median final atrophy area was 0.844 [IQR 0.06 – 1.4].
The progression of macular atrophy in pattern dystrophies appears to be slow compared to age-related macular degeneration. Visual acuity is usually preserved in most of cases. Nevertheless, some patients had more severe forms in our study, with choroidal neovascularization or large atrophy. Further studies are necessary to confirm this trend and to correlate the progression of atrophy in pattern dystrophies with genetic data.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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