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Stacey L Ackerman, Joseph B Ciolino, Julia M Williams, David A Hollander; Superior efficacy of Lastacaft® versus Pataday in grass- and tree-allergic subjects. Invest. Ophthalmol. Vis. Sci. 2016;57(12):312. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
Due to Lastacaft’s effect on epithelial tight junctions1, efficacy for ocular itching might be influenced by the type of allergen sensitivity. Our aim was to assess the onset of effect of Lastacaft versus Pataday administered 16 and 24 hours prior to exposure to allergen in subjects sensitized to grasses and trees and with a history of allergic conjunctivitis.1Ono SJ, Lane K. Comparison of effects of alcaftadine and olopatadine on conjunctival epithelium and eosinophil recruitment in a murine model of allergic conjunctivitis. Drug Design, Development and Therapy. 2011;5:77-84.
Pooled data from two double-masked, multicenter studies using the conjunctival allergen challenge (CAC) model were analyzed in this post-hoc analysis. Subjects who qualified at baseline received one drop of Lastacaft® (0.25% alcaftadine) or Pataday® (olopatadine 0.2%) 16 hours and 24 hours prior to CAC. Itching was assessed after 3, 5, and 7 minutes. Mean differences, change from CAC-baseline, percent CAC-baseline itching, and percent responders with <1 itching were considered.
A total of 111 subjects were treated with Lastacaft (48 grass-, 9 tree-sensitized) or Pataday (47 grass- and 7 tree-sensitized).In grass-allergic subjects, 16 hours after dosing and 3 minutes post-CAC, Lastacaft was superior to Pataday with a mean difference of -0.42 (p=0.011). Change from baseline itching was -2.2 for Lastacaft versus -1.5 for Pataday (p=0.002); % baseline itching was -80.3% for Lastacaft and -60.2% for Pataday (p=0.005). Percent responders with scores <1 was also higher with Lastacaft (66.7%) than Pataday (47%), p=0.015.In tree-allergic subjects, at 24 hours after dosing and 3 minutes post-CAC, Lastacaft showed the greatest change from baseline: -2.4 for Lastacaft versus -1.1 for Pataday (p=0.048). As % baseline itching, Lastacaft was -83.3% versus -41.4% for Pataday (p=0.045).
Lastacaft showed superior efficacy to Pataday for ocular itching at 16 and 24 hours in grass- and tree-allergic subjects at 3 minutes post-CAC. It has been hypothesized that Lastacaft offers epithelial barrier protection, which may explain the superior activity of Lastacaft compared to Pataday immediately after allergen exposure.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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