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Daisuke Shiba, Eri Hirano, Sayaka Adachi, Takeshi Ono, Kenya Yuki, Kazuo Tsubota; Comparison of reproducibility in quantitative evaluation of glaucoma between structure and function. Invest. Ophthalmol. Vis. Sci. 2016;57(12):346.
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© ARVO (1962-2015); The Authors (2016-present)
A precise examination method for evaluating glaucomatous optic neuropathy (GON) has an advantage to detect progression early and properly. The objective of the present study is to compare reproducibility in assessing GON between macular ganglion cell complex thickness (GCCT) with spectral-domain optical coherence tomography (SD-OCT) and visual field sensitivity (VFS) with standard automated primetry (SAP).
In this prospective study, we included glaucoma patients with visual field defect above -18dB of mean deviation value. Eyes with cataract or any other ocular abnormality or history of intraocular surgery except successful glaucoma surgery were excluded. The included patients underwent SAP by Humphry field analyzer with central 30-2 program and GCCT measurement by SD-OCT (Nidek; RS-3000 Advance) with macular scan. The same examinations were repeated at the next visit for less than two months. We used mean GCCTs in superior semicircle (SSC) with the radius of 3mm and inferior semicircle (ISC) with the same radius as structural measures. The center of SSC or ISC was positioned at the fovea. Meanwhile, mean VFSs of superior hemi-field (SHF) and inferior hemi-field (IHF) were adopted as functional measures. We adopted intra-class correlation coefficient (ICC) between the two inter-visit same measurements as an index of reproducibility.
The mean first / second GCCTs were 84.1±10.4µm / 83.9±10.5µm in SSC and 74.6±1.5µm / 74.6±1.51µm in ISC. Mean VFSes at first / second visit was 25.6±5.6dB / 25.4±5.6dB in IHF, 22.9±7.5dB / 22.9±7.1dB in SHF. ICC of GCCT in SSC was 0.987 [95%CI: 0.976-0.993] while ICC of VFS in IHF was 0.957 [95%CI: 0.922-0.976]. ICC of GCCT in ISC was 0.983 [95%CI: 0.970-0.991] while ICC of VFS in SHF was 0.959 [95%CI: 0.925–0.977].
Structural measurements had higher reproducibility than functional measurements in this study population.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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