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Moritz Pettenkofer, C.P. Lohmann, Lukas Reznicek; Structure-function relationship between Heidelberg Retina Tomography (HRT) and Heidelberg Edge Perimeter (HEP) parameters in glaucoma suspects. Invest. Ophthalmol. Vis. Sci. 2016;57(12):377.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the relationship between functional parameters of repeated flicker defined form perimetry with HEP and structural parameters of the Heidelberg Retina Tomograph (HRT) in glaucoma suspects with normal findings in achromatic standard automated perimetry (SAP).
34 Patients with optic nerve heads clinically suspicious for glaucoma and normal SAP findings were enrolled in this prospective study. Each participant underwent visual field testing with HEP (Heidelberg Engineering, Heidelberg, Germany) at two consecutive visits. Additionally, each patient received an HRT examination (Spectralis, Heidelberg Engineering, Heidelberg, Germany) with Glaucoma Probability Score (GPS) and Moorfield Regression Analysis (MRA). Correlations of HRT based structural parameters with HEP based functional outcome values were investigated.
A consecutive series of 34 study eyes of 34 Patients were prospectively included. Highly significant correlations were observed between global mean deviation (MD) and pattern standard deviation (PSD) of HEP and HRT based GPS (r=-0.536, p=0.002 for MD and r=0.593, p<0.001 for PSD). Also, sectorial MD and PSD of HEP showed significant correlations with GPS in each of the six evaluated sectors with the highest correlations between HEP and GPS for the temporal (r=-0.597, p<0.001 for MD and r=0.611, p<0.001 for PSD) and nasal inferior sectors (r=-0.580, p=0.001 for MD and r=0.600, p<0.001 for PSD). HEP based parameters correlated with MRA significantly only for the temporal inferior sector (r=-0.397, p=0.03 for MD)
In glaucoma suspects with normal SAP findings, global structural HRT based parameters highly correlated with visual field defects in HEP, but did not correlate with structural HRT based MRA parameters except for the temporal inferior sector.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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