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Jung Yeul Kim, Min Su Kim, Hyung bin Lim, Kyung sup Shin; Longitudinal change of macular, ganglion cell layer, and retinal nerve fiber layer thickness after vitrectomy: twelve-month observational study. Invest. Ophthalmol. Vis. Sci. 2016;57(12):440.
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© ARVO (1962-2015); The Authors (2016-present)
We performed a prospecitve, observational study to analyze the longitudinal changes in the macular, ganglion cell–inner plexiform layer (GC-IPL), and peripapillary retinal nerve fiber layer (RNFL) thicknesses after vitrectomy.
Patients diagnosed with intraocular lens dislocation with no evidence of other vitreoretinal disease were analyzed. All of the patients underwent a conventional vitrectomy and intraocular lens trans-scleral fixation and followed for 12 months after vitrectomy. Using spectral domain optical coherence tomography (SD-OCT), we measured the thickness of the macular, GC-IPL, and peripapillary RNFL in the vitrectomized and fellow control eyes before surgery and at 1, 3, 6, and 12 months after surgery. We evaluate the change of thickness of retina in OCT measurements after surgery with the passage of time.
There were no significant differences in the thickness of the macular, GC-IPL, and peripapillary RNFL using OCT between the study and fellow eyes from baseline. Postoperative central macular thickness did not show significant differences compared to baseline values. The mean GC-IPL thickness was increased at 1 month after surgery from baseline (p=0.038), but there were no significant differences at 3 months postoperatively. The mean RNFL thickness was significantly increased at 1 month (p=0.001) and 3 months (p=0.011) after vitrectomy from baseline, but there were no differences 6 months postoperatively. The mean foveal, GC-IPL and RNFL thicknesses of the study eye compared to the fellow eye were significantly increased at 1 month (p=0.034), at 1 month (p=0.028), and at 1 (p=0.015) to 3 months (p=0.039) after surgery, respectively. No significant differences in intraocular pressure and all disc parameters were found between study and fellow eyes during a follow-up of 12 months after surgery.
Transient increase of both macular and GC-IPL thicknesses was observed at 1 month following vitrectomy, and the postoperative RNFL thickness was increased until 3 months after surgery and thereafter, it returned to the preoperative level. There was no significant change in IOP and all disc parameters before and after surgery. These findings should be considered in the process of analyzing the retinal layer thickness obtained from OCT in patients with a history of vitrectomy.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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