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Taro Chaya, Akihiro Matsumoto, Yuko Sugita, Satoshi Watanabe, Ryusuke Kuwahara, Masao Tachibana, Takahisa Furukawa; Unexpected functional roles of horizontal cells in the retinal circuit. Invest. Ophthalmol. Vis. Sci. 2016;57(12):589.
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© ARVO (1962-2015); The Authors (2016-present)
Interneurons play pivotal roles in information processing in the neural circuit. Retinal horizontal cells (HCs) are inhibitory interneurons that are known to be involved in lateral inhibition to increase spatial resolution in vision. However, exact functional roles of HCs in the retina still remain unclear.
We established HC depletion (dHC) mice and analyzed electrophysiological properties of dHC retinas under non-degenerative condition of the retina.
Depletion of HCs resulted in impairment of firing properties and functional subtype formation of retinal ganglion cells (RGCs) in addition to enlargement of receptive field of RGCs. Furthermore, we found that HCs play an essential role in global light adaptation. At an individual level, dHC mice exhibited abnormal visual function in optokinetic responses.
Our current study uncovers versatile functional roles of HCs in the retinal circuit.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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