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Hyoung Won Bae, Eun Min Kang, Si Hyung Lee, Gyu Ah Kim, Gong Je Seong, Chan Yun Kim; Asymmetry of Peak Thicknesses between the Superior and Inferior Retinal Nerve Fiber Layers Measured by Spectral Domain Optical Coherence Tomography for Early Glaucoma Detection in Patients with Myopia. Invest. Ophthalmol. Vis. Sci. 2016;57(12):857.
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© ARVO (1962-2015); The Authors (2016-present)
To assess whether superior and inferior asymmetry in the thicknesses of the peripapillary retinal nerve fiber layer (pRNFL) using optical coherence tomography (OCT) is useful for early detection of glaucoma in patients with myopia.
A total of 33 myopic eyes with early glaucoma and 37 myopic eyes without glaucoma were retrospectively enrolled. Two simple methods for measuring asymmetry between the thicknesses of the superior and inferior pRNFL were identified as a ratio using spectral domain OCT. One was the ratio between the superior and inferior peak thicknesses (PTR), and the other was the ratio between the superior and inferior average thicknesses (ATR). The diagnostic abilities of the PTR and ATR were compared to the color code classification using OCT.
For the all myopic eyes, the areas under the receiver operating characteristic curves (AUCs) of the PTR, ATR, quadrants color code classification, and clock-hour color code classification were 0.888, 0.755, 0.875, and 0.779 respectively. Both PTR and ATR did not show a better diagnostic ability compared to color code classifications. However, for the high myopic eyes (spherical equivalent < -6 D), the AUCs of the PTR, ATR, quadrants color code classification, and clock-hour color code classification were 0.983, 0.682, 0.741, and 0.651 respectively. PTR showed a significantly better diagnostic performance for early glaucoma than the ATR, quadrants color code classification, and clock-hour color code classification in high myopic cases (p=0.003, 0.006, and <0.001, respectively).
The PTR could be the best method with considerable diagnostic ability for early glaucoma detection in patients with high myopia.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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