Purchase this article with an account.
Gerhard Garhofer, Leopold Schmetterer, Katarzyna Witkowska, Piotr Wozniak, Ahmed Bata, Klemens Fondi, Gerald Schmidinger, Niklas Pircher, Doreen Schmidl, Rene Marcel Werkmeister; Effect of CACICOL® on corneal epithelial healing after cross-linking in patients with keratoconus. Invest. Ophthalmol. Vis. Sci. 2016;57(12):909.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
The aim of the present study was to investigate the effect of CACICOL® on corneal epithelial healing after epi-off corneal cross-linking in patients with keratoconus . CACICOL® is an ophthalmic solution based on the technology of RGTAs (ReGeneraTingAgents) consisting of bioengineered analogues of heparan sulphate glycosaminoglycans, that were shown to improve tissue healing.
Randomized, double-masked, parallel group study. Forty patients with keratoconus undergoing epi-off cross-linking were randomized to receive either CACICOL® or Genteal HA® (hyaluronic acid 0.3%) eye drops added to the standard treatment regimen. Patients received the study eye drops every second day. The primary efficacy outcome was corneal wound healing rate, defined as size of defect over time measured using two independent methods: ultrahigh-resolution OCT and slit lamp photography with fluorescein staining.
Wound healing was significantly faster in patients under CACICOL® therapy (4.3 ± 1.2 days) as compared to Genteal HA® therapy (6.0 ± 2.0 days; p = 0.019 between groups). The corneal wound healing rate was significantly faster in patients under CACICOL® therapy as compared to Genteal HA® therapy. This was demonstrated with both OCT images (p < 0.01) as well as from fluorescein photographs (p < 0.01)
CACICOL® significantly improves epithelial wound healing after epi-off cross-linking in patients with keratoconus. Ultrahigh resolution OCT is an attractive tool to study epithelial corneal wound healing.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
This PDF is available to Subscribers Only