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Julien Gozlan, Martine Mauget-Faysse, Olivier Lichtwitz, Nicolas Leveziel; Retinal Microvascular Alterations Related To Diabetes assessed by Optical Coherence Tomography Angiography.. Invest. Ophthalmol. Vis. Sci. 201657(12):.
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© ARVO (1962-2015); The Authors (2016-present)
Fluorescein angiography has been so far the gold-standard test to assess diabetic macular ischemia (DMI), an important cause of visual impairment in diabetic patients. The aim of this study was to investigate foveal avascular zone (FAZ) and perifoveal microcirculation changes in eyes with non-proliferative diabetic retinopathy (NPDR) using optical coherence tomography angiography (OCTA).
Cross-sectional study including eyes of diabetic patients affected with NPDR. All patients underwent medical history, best-corrected visual acuity (BCVA) measurement, slit-lamp and fundus examination and multicolor, SD-OCT, Swept-Source OCT. OCTA, a new and non-invasive vascular imaging technique, was performed in order to assess macular superficial and deep capillary plexus in each included eye.
Fifty-eight eyes of 35 patients with a mean age of 61.8 with NPDR were included in this study. Among them, there was 19 eyes with mild NPDR, 24 eyes with moderate NPDR and 15 eyes with severe NPDR. There was a significant progression between NPDR stages for FAZ grade (p < 0.0001), surface (p = 0.0036) and perimeter (p = 0.0001), and for superficial capillary plexus non-perfusion index (NPI) (p = 0.0009). Moreover, a significant correlation was found between NPI and BCVA (p = 0.007).
OCTA is a new retinal vascular imaging technique which is able to explore DMI in a non-invasive manner in NPDR. NPI, a newly described OCTA index, is able to explore, in a single measurement, both foveal and perifoveal microcirculation.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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