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John W Crabb; AMD and glaucoma proteomics: Insights to mechanisms and biomarkers. Invest. Ophthalmol. Vis. Sci. 201657(12):.
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© ARVO (1962-2015); The Authors (2016-present)
Presentation Description :
Proteomic research approaches are increasingly providing new molecular insights to ocular diseases. A defining advantage of proteomics is the capability to identify and quantify thousands of proteins without prespecification of analytes. Proteomic contributions will be presented to current understandings of AMD and glaucoma pathologies and the identification of potentially useful biomarkers. For AMD, focus will be upon proteomic studies of drusen and lipofuscin, oxidative modifications in AMD ocular tissues and plasma and quantitative analyses of macular Bruch’s membrane/choroid with AMD progression and category. For glaucoma, emphasis will be on recent global quantitative analyses of optic nerve head, orbital optic nerve, retina and peripapillary sclera from monkeys with laser-induced, unilateral early experimental glaucoma (EG) that have revealed significantly altered proteins at high IOP EG and suggest major proteomic differences between high IOP and mild IOP EG.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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