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sheila pabon, Tom lindquist, Tom Miller, Bennie H Jeng; Systemic Candida Infections in Donors for Corneal Transplantation. Invest. Ophthalmol. Vis. Sci. 2016;57(12):1233.
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© ARVO (1962-2015); The Authors (2016-present)
<div>To determine the rate of post keratoplasty fungal infection with the use of corneal tissue donors with known fungal positive medical history following treatment of tissue with prophylactic 5% povidone-iodine flush to the donor's face and eye.</div>
<div>A prospective analysis of 42 corneal donors with a documented medical history of systemic fungal infection. These patients were targeted for corneal recovery between January 2010 and November 2010. A standard aseptic swab of the donor's face and corneas pre and post application of 5% povidone iodine solution was done. Culture results were analyzed in relationship to donor medical history and potential post-transplantation infections.</div>
Eighty-four eyes from 42 patients were swabbed for cultures during the study period. Seven eyes (8.1%) were positive for fungal growth before treatment with 5% povidone iodine solution. Microorganisms recovered included Candida albicans 2 (2.38%), Yeast 2 (2.38%), Candida glabrata (1.19%), Candida parapsilosis 1 (1.19%) and Rhodotorula sp. 1 (1.19%). No post-5% povidone iodine culture swab tested positive for fungal growth. There were no cases of fungal infection in any postkeratoplasty patients.
<div> The overall rate of fungal infections following keratopplasty using corneal donor tissue from donor with fungal positive medical history is low. Prophylactic 5% povidone-iodine flush was successful at decreasing fungal bio-burden prior to corneal harvesting and storage.</div>
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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