September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Systemic Candida Infections in Donors for Corneal Transplantation
Author Affiliations & Notes
  • sheila pabon
    Ophthalmology, University of Maryland MEdical Center, Baltimore, Maryland, United States
  • Tom lindquist
    SightLife, Inc, Seattle, Washington, United States
  • Tom Miller
    SightLife, Inc, Seattle, Washington, United States
  • Bennie H Jeng
    Ophthalmology, University of Maryland MEdical Center, Baltimore, Maryland, United States
  • Footnotes
    Commercial Relationships   sheila pabon, None; Tom lindquist, None; Tom Miller, None; Bennie Jeng, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 1233. doi:
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      sheila pabon, Tom lindquist, Tom Miller, Bennie H Jeng; Systemic Candida Infections in Donors for Corneal Transplantation. Invest. Ophthalmol. Vis. Sci. 2016;57(12):1233.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose : <div>To determine the rate of post keratoplasty fungal infection with the use of corneal tissue donors with known fungal positive medical history following treatment of tissue with prophylactic 5% povidone-iodine flush to the donor's face and eye.</div>

Methods : <div>A prospective analysis of 42 corneal donors with a documented medical history of systemic fungal infection. These patients were targeted for corneal recovery between January 2010 and November 2010. A standard aseptic swab of the donor's face and corneas pre and post application of 5% povidone iodine solution was done. Culture results were analyzed in relationship to donor medical history and potential post-transplantation infections.</div>

Results : Eighty-four eyes from 42 patients were swabbed for cultures during the study period. Seven eyes (8.1%) were positive for fungal growth before treatment with 5% povidone iodine solution. Microorganisms recovered included Candida albicans 2 (2.38%), Yeast 2 (2.38%), Candida glabrata (1.19%), Candida parapsilosis 1 (1.19%) and Rhodotorula sp. 1 (1.19%). No post-5% povidone iodine culture swab tested positive for fungal growth. There were no cases of fungal infection in any postkeratoplasty patients.

Conclusions : <div> The overall rate of fungal infections following keratopplasty using corneal donor tissue from donor with fungal positive medical history is low. Prophylactic 5% povidone-iodine flush was successful at decreasing fungal bio-burden prior to corneal harvesting and storage.</div>

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.


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