Abstract
Purpose :
To compare postoperative outcomes of anterior lamellar keratoplasty (ALK), big-bubble deep anterior Lamellar keratoplasty (DALK) and penetrating keratoplasty (PKP) for macular corneal dystrophy (MCD).
Methods :
Retrospective analysis of 10 ALK eyes, 24 DALK eyes and 140 PKP eyes in 98 patients with MCD.
Results :
Median follow-up was 3.62 (range 1.04-16.02) years and 5.89 (range 1.0-17.0) years in the lamellar keratoplasties and PKP groups, respectively. Median best-corrected visual acuity (BCVA) was 20/80 and 20/40 in ALK and DALK groups, respectively (P=0.006). Median BCVA was 20/40 in PKP group. The likely hood of achieving 20/40 or better was higher in PKP vs. DALK groups, but was not statistically significant. Graft survived in 30% (3 eyes) and 100% (24 eyes) in ALK and DALK groups, respectively (P=0.0001). Graft survived in 95% (133 eyes) in PKP group. Recurrence (71.4%) was the main cause of graft failure in ALK group, while recurrence (42.8%) and irreversible rejection (57.1%) were the main causes of graft failure in PKP group.
Conclusions :
ALK for MCD is associated with poor prognosis for graft survival and visual result. In comparison to PKP, DALK has a higher probability of graft survival, a lower complication rate, and a comparable visual result.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.