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Jessie Lemp, Jami R Kern, Amanda Shows, Huagang Chen; A comparison of residual peroxide profiles after neutralization of two marketed one-step 3% hydrogen peroxide systems. Invest. Ophthalmol. Vis. Sci. 2016;57(12):1488.
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© ARVO (1962-2015); The Authors (2016-present)
To compare the residual peroxide (H2O2) profiles of Clear Care Plus (CCP) and PeroxiClear (PC) after neutralization in laboratory-cycled cases and patient-used cases.
Residual H2O2 of neutralized CCP and PC (N=5 CCP and PP cups/discs) was measured via UV spectroscopy in parts per million (ppm) after 1, 15, 30, 45, 60, 75, 90, and 100 cycles at the manufacturer-recommended neutralization time (NT; CCP=6hrs and PC=4hrs) at ambient room temperature. Additionally, 132 subjects used CCP and PC systems in a randomized order for 30 days each to disinfect their silicone hydrogel lenses. Lens cases were collected at Day 30, and the appropriate solution was added to each case (10mL/case) to measure residual H2O2 via UV spectroscopy at NT. Neutralization rates were also determined in triplicate single-cycled cases at neutralization time points of 5, 15, 30, 45, 60, 120, 240, and 360 minutes and in ten 30-day used cases at 120, 180, 240 (CCP and PC), and 360 (CCP only) minutes.
At NT, the mean residual H2O2 for CCP was below 10ppm after 30 cycles and 5ppm after 100 cycles, while PC averaged 55ppm and 72ppm after 30 and 100 cycles, respectively. In 30-day used cases, residual H2O2 of CCP and PC at NT was 26.2±41.17 and 229.7±280.13, respectively (p<0.001). In the neutralization rate studies, CCP had significantly lower residual H2O2 than PC at all tested neutralization time points up to 120 min in unused cases and up to 180 min in 30-day used cases (p<0.05 for both) with a trend towards lower residual H2O2 in both studies at 240 min (p<0.10).
Both the CCP and PC H2O2 systems used by study subjects resulted in slightly higher residual H2O2 concentrations at NT compared to the systems cycled in the lab; however, the manufacturer-recommended 6 hour NT of CCP allows for more complete neutralization of H2O2 than the 4 hour NT recommended with PC. 99% of the 30-day patient used CCP systems neutralized H2O2 to a level of 100ppm or less, which is below the level detectable by the ocular tissues.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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