September 2016
Volume 57, Issue 12
ARVO Annual Meeting Abstract  |   September 2016
Comparison between Multimodal Imaging and OCT Angiography in the diagnosis of Age Related Choroidal Neovascularization
Author Affiliations & Notes
  • Maurizio Mete
    Ophthalmology, Ospedale Sacro Cuore Don Calabria, Negrar (VR), Italy
  • Antonio Peroglio Deiro
    Ophthalmology, Ospedale Sacro Cuore Don Calabria, Negrar (VR), Italy
  • Massimo Guerriero
    Computer Science, University of Verona, Verona, Italy
  • Grazia Pertile
    Ophthalmology, Ospedale Sacro Cuore Don Calabria, Negrar (VR), Italy
  • Footnotes
    Commercial Relationships   Maurizio Mete, None; Antonio Peroglio Deiro, None; Massimo Guerriero, None; Grazia Pertile, None
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 1635. doi:
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      Maurizio Mete, Antonio Peroglio Deiro, Massimo Guerriero, Grazia Pertile; Comparison between Multimodal Imaging and OCT Angiography in the diagnosis of Age Related Choroidal Neovascularization. Invest. Ophthalmol. Vis. Sci. 2016;57(12):1635.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose : To assess inter- and intraobserver agreement between multimodal imaging (SD-OCT, fluorescein and indocyanine angiography) and OCT angiography for the diagnosis of Choroidal Neovascularization ( CNV ) in Age Related Macular Degeneration ( AMD ).

Methods : Cross sectional study. Twenty-nine consecutive patients referred to our ophtalmologic department with a suspicious exudative AMD were studied by multimodal imaging (HRA Spectralis, Heidelberg Engenieering, Germany) and OCT Angiography (Optovue RTVue XR Avanti, Freemont, USA). The exams were performed in the same day. Two independent examiners reviewed the images. Cohen’s K coefficient was calculated to evaluate the intra- and interobserver agreement for both techniques.

Results : Twenty-nine consecutive patients were included (8 males, 21 females; mean age 73 years – range 67-89). A good inter-observer agreement was observed (K =0.6568) for multimodal imaging and resulted statistically significant (P = 0.0002). Similar results were achieved also for OCT angiography (K=0.6778; P=0.0001). The intra-observer agreement between the two imaging techniques resulted optimal (K=0.8284); the area under the ROC curve was 0.98. The analysis was repeated by another observer, who substantially replied the results.

Conclusions : The gold standard technique for CNV diagnosis includes FA, ICGA and OCT. Usually they have to be considered together to reach the highest diagnostic power: nevertheless, achieving and analysing all the images could be extremely time-consuming. OCT angiography is a new imaging tool that could allow obtaining angiographic-like images in a very quick time, with no need of dye injections. Our results showed that OCT angiography is a reliable tool for the diagnosis of CNV in AMD and may be considered as a substitute of conventional techniques, with both a substantial saving of time and a reduction of patient discomfort.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.


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