OCT-ANGIOGRAPHY FEATURES OF CHOROIDAL NEOVASCULARIZATION SECONDARY TO ANGIOID STREAKS

Abstract

Purpose : Choroidal neovascularization (CNV) is one of the main complications of an angioid streaks (AS). Aim of the study is to describe the Optical Coherence Tomography Angiography (OCT-A) features of CNV secondary to AS.

Methods : We retrospectively analyzed 9 patients presenting between September 2015 and November 2015 at the Medical Retina Service of the University Vita-Salute San Raffaele in Milan . Each patient underwent multimodal retinal imaging: multicolor imaging, fluorescein angiography (FA), spectral-domain (SD)-OCT, OCT-A (AngioPlex™, CIRRUS HD-OCT models 5000, Carl Zeiss Meditec, Inc., Dublin, USA). OCT-A features of CNV were analyzed and two types of denomination were proposed: “interlacing” and “tangled” vascular network. Automatic segmentation provided by the machine software was manually adjusted.

Results : Thirteen eyes of 9 patients (5 males / 4 females) with AS and CNV (mean age 60.8 ± 8.2 years) were included for analysis. In all eyes we found agreement between OCTA, FA and SD-OCT images in detecting CNV. CNV appeared on OCT-A as a hyper-intense vascular network of variable size. Seven eyes (53.8 %) showed an “interlacing” network and 6 eyes (46.2 %) a “tangled” network. The interlacing appearance was more often associated with signs of activity on multimodal imaging.

Conclusions : OCT-A is a very useful non-invasive tool to detect and characterize CNV associated with AS.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.