September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Development and evaluation of the novel fundus oximetry
Author Affiliations & Notes
  • Shinichiro Ishikawa
    Facility of Medicine Department of Ophthalmology , Saga University, Saga, Saga, Japan
  • Yukiyasu Yoshinaga
    Kyushu University, Fukuoka, Japan
  • Daisuke Nakamura
    Kyushu University, Fukuoka, Japan
  • Tatsuo Okada
    Kyushu University, Fukuoka, Japan
  • Tatsuro Ishibashi
    Kyushu University, Fukuoka, Japan
  • Hiroshi Enaida
    Facility of Medicine Department of Ophthalmology , Saga University, Saga, Saga, Japan
  • Footnotes
    Commercial Relationships   Shinichiro Ishikawa, None; Yukiyasu Yoshinaga, None; Daisuke Nakamura, None; Tatsuo Okada, None; Tatsuro Ishibashi, None; Hiroshi Enaida, Kyushu University (P), NIDEK (F)
  • Footnotes
    Support  Ministry of Education, Culture, Sports, Science and Technology, Japan.Translational Research C-14
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 1655. doi:
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    • Get Citation

      Shinichiro Ishikawa, Yukiyasu Yoshinaga, Daisuke Nakamura, Tatsuo Okada, Tatsuro Ishibashi, Hiroshi Enaida; Development and evaluation of the novel fundus oximetry. Invest. Ophthalmol. Vis. Sci. 2016;57(12):1655.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose : We developed a novel fundus oximetry and evaluate of optical density ration (ODR) about the retinal major vessels and the microcirculation areas under normal and in hypoxic conditions.

Methods : In this system ODR measured by the original algorithm and software. The software makes major vessel ODR mapping images by calculated ODR with convergence index filter (MV mode). Also, the software makes whole fundus ODR mapping images by calculated arterial red blood cells' ODR with spatial affected effect (WF mode). Systemic hypoxia was induced in healthy volunteers by held their breath under pulse oximeter monitored condition.

Results : At MV mode, ORDs were measured as 0.73±0.024 for arterioles and 1.12±0.096 for venules in normal subjects (mean ± SD, N = 4, P =0.029). At WM mode, ODR mapping images showed wider ODR area as became lower SpO2.

Conclusions : The novel fundus oximetry is first whole fundus' ODR measurable system in non-invasive condition.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.


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