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Vidal Soberon, Raul Velez-Montoya, Gerardo Garcia-Aguirre, lorena wheelock, Virgilio Morales-Canton, Hugo Quiroz-Mercado, Guillermo Salcedo; Comparison Of Vitreous Humor Characteristics Of Children And Adults With Enhanced Vitreous Imaging SD-OCT. Invest. Ophthalmol. Vis. Sci. 2016;57(12):1666. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
Enhanced vitreous imaging (EVI) provides a way to visualize and study the vitreous humor (VH) in normality and disease conditions. The purpose of this retrospective, observational and comparative study is to analyze the VH of adults and children using EVI. The objective is to determine if there are differences between both populations regarding specifically the area of the pre-macular bursa (PMB) and the vitreous septum (VS).
Retrospective analysis of EVIs performed with the Spectralis HRA-OCT of 36 healthy volunteers, 17 adults (age >21 years) and 19 children (age <21 years). Institutional review board approval and written informed consent from all the volunteers was obtained prior to image acquisition. The study was done under the tenants of the Declaration of Helsinki. EVIs were analyzed for visualization the PMB and the VS in both populations. The area of both structures was measured using the software’s caliper. Means for the two groups were compared using an independent samples t-test.
Results: EVIs for 66 eyes were studied. Mean PMB area for adults was 1.689 µm2 (SD: 0.638; SEM: 0.116); for children was 1.483 µm2 (SD: 0.530; SEM: 0.096). Mean VS area for adults was 0.282 µm2 (SD: 0.137; SEM: 0.024); for children was 0.466 µm2 (SD: 0.186; SEM: 0.034). All measurements presented a normal distribution. Independent samples t-test to compare the means of PMB areas resulted in a t-value: 1.354 (58 df), p-value: 0.181 (95% confidence interval [CI]: -0.098 - 0.508). Independent samples t-test to compare the means of VS area resulted in a t-value: -4.440 (60 df), p-value: 0.000 (95% CI: -0.266 - -0.100).
Statistical difference exist when comparing the area of the VS of adults and children. No statistical difference exist when comparing the PMB. VH of adults and children may differ on degeneration of more dense structures over time, such as the VS (hence a smaller area on adults), and expansion of degenerated spaces, such as the PMB (hence a larger area on adults).
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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