September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Effect of selective oral inhibition of CCR2/5 chemokine receptors compared to intravitreal ranibizumab on diabetic macular edema (DME)
Author Affiliations & Notes
  • Brian B Berger
    Retina Research Center, Austin, Texas, United States
  • Jeremy Gale
    Pifzer Inc., Cambridge, Massachusetts, United States
  • Steven Gilbert
    Pifzer Inc., Cambridge, Massachusetts, United States
  • Sergei Popa
    Spitalul Clinic Republican, Chisnau, Moldova (the Republic of)
  • Marla Sultan
    Pifzer Inc., Cambridge, Massachusetts, United States
  • Ronald Schachar
    Pifzer Inc., Cambridge, Massachusetts, United States
  • Rob Webster
    Pifzer Inc., Cambridge, Massachusetts, United States
  • Christelle Perros-Huguet
    Alexion Pharmaceutical, Inc., Cheshire, Connecticut, United States
  • Footnotes
    Commercial Relationships   Brian Berger, Aciont Inc. (F), Aerpio Therapeutics (F), Alcon Laboratories (C), Alimera Advisory Board (C), Allegro Ophthalmics (F), Allergan (C), Ampio Pharmaceuticals (F), Bausch & Lomb (F), Daiichi Sankyo (F), Diabetic Retinopathy Clinical Research (F), Genentech (F), GlaxoSmithKline (F), Novartis (F), Ophthotech (F), Panoptica (F), Pfizer (F), Santen Inc. (C), StemCells Inc (F), Tyrogenex Inc (F), University of Virginia (F); Jeremy Gale, Pfizer, Inc. (E); Steven Gilbert, Pfizer, Inc. (E); Sergei Popa, Astellas Pharma (F), Eli Lilly and Company (F), Gilead Sciences (F), Idenix Pharmaceuticals (F), J&J Pharmaceuticals (F), Merck Pharmaceuticals (F), Pfizer, Inc. (F), Sanofi (F), UCB Pharma (F); Marla Sultan, Pfizer, Inc. (E); Ronald Schachar, Pfizer, Inc. (E); Rob Webster, Pfizer, Inc. (E); Christelle Perros-Huguet, Alexion Pharmaceuticals (E)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 2109. doi:
  • Views
  • Share
  • Tools
    • Alerts
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Brian B Berger, Jeremy Gale, Steven Gilbert, Sergei Popa, Marla Sultan, Ronald Schachar, Rob Webster, Christelle Perros-Huguet; Effect of selective oral inhibition of CCR2/5 chemokine receptors compared to intravitreal ranibizumab on diabetic macular edema (DME). Invest. Ophthalmol. Vis. Sci. 2016;57(12):2109.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

  • Supplements

Purpose : Chemokine receptor ligands are elevated in the aqueous and vitreous in diabetics and the MCP-1/CCR2 receptor axis appears to play an important role in alterations to the blood-retinal barrier in diabetes. We hypothesized that combined blockade of CCR2 and CCR5 receptors would improve DME. Hence, the efficacy and safety of a novel, highly specific and long-acting dual CCR2/5 receptor antagonist, PF-04634817, on DME was assessed in a multinational, multicenter, randomized, double-masked, placebo-controlled, parallel group trial of DME patients with Type 1 and 2 diabetes.

Methods : DME patients with ETDRS BCVA of 24-78 letters and spectral domain optical coherence tomographic central retinal thickness (CRT) of >250mm in the study eye at baseline were randomly assigned to receive for 12 weeks either PF-04634817 200mg orally once daily plus masked sham therapy given monthly or ranibizumab (0.3 or 0.5mg) intravitreal injection monthly plus daily oral placebo. Change from baseline at 12 weeks in BCVA, CRT, fluorescein angiographic (FA) area of leakage and grades of diabetic retinopathy (DR) were assessed.

Results : 199 subjects, with mean (SD) BCVA in the study eye of 62.3 (+11.43) letters and a mean CRT of 453.1 mm (+159.55) were randomized. Following 12 weeks of dosing mean BCVA improved 4.4 (+8.21) and 6.4 (+7.83) letters, and mean CRT decreased 24.5mm (+97.74) and 110.4mm (+130.53) in the PF-04634817 and ranibizumab groups, respectively. The least squares mean difference in BCVA was 2.41 letters (80% CI: – 3.91 to 0.91) in favor of ranibizumab. There were 6.9% and 15.4% 3-line gainers, a mean 0.17mm2 (+4.96) and 7.33mm2 (+9.28) decrease in FA leakage area, and a mean 0.0 (+0.61) and 0.5 (+1.03) reduction in grades of DR with PF-04634817 and ranibizumab, respectively. Adverse events (AEs) following PF-04634817 treatment were mostly mild, with the only treatment-related AE of headache exceeding 1% incidence.

Conclusions : Although there was a mean 4.4 letter improvement in BCVA following oral treatment with PF-04634817, it was unaccompanied by anatomical improvements in the retina of the study or fellow eyes. This suggests that changes in BCVA following monotherapy of selective inhibition of CCR2/5 for DME should be interpreted with caution, but further study in combination with other agents may be of value.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.


This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.